Miguel L. Grau
Bioinformatician
Personal statement
I’m currently working as a Bioinformatician split between Monash University in the Disease Ecology and Evolutionary Genetics group (Department of Microbiology) led by Professor D. Vijaykrishna and the World Health Organization (WHO) Collaborating Centre for Reference and Research on Influenza at the Victorian Infectious Diseases Reference Laboratory (VIDRL) in Melbourne. My main task consist in the analysis of Next Generation Sequencing data, especially focused in the evolution aspects of pathogens.
My work primarily consists of designing data analysis pipelines to answer a huge variety of biological questions. These tasks include the use of illumina/ionTorrent/pacbio/nanopore data to perform new assemblies, within host population analysis (iSNV), phylogenetics, virus-host interactions studies, analysis of factors affecting transmission of pathogens (bottlenecks), identification of positive selection, among others.
My pipelines, written mainly in Python and R, make use of multiple software tools, as well as our own libraries and scripts.
Job Experiences
Bioinformatician.
WHO Collaborating Centre for Reference and Research on Influenza. Australia.
Designing pipelines to optimise phylogenetic analysis.
Sep 2019 - Present
Technical Officer. Bioinformatics.
Department of Microbiology at Monash University. Australia.
Pipelines design for NGS data, especially focused on the evolution aspects of pathogens, for the Disease Ecology and Evolutionary Genetics lab.
2017 - Present
Research Technician. Bioinformatics.
Okinawa Institute of Science and Technology. Japan.
Build pipelines to analyse NGS data for the Ecology and Evolution Unit.
2013 - 2017
Research Technician.
Group of Photovoltaic and Optoelectronic Devices, University Jaume I. Spain.
Java desktop applications, Design of web-tools for characterization of photovoltaic cells. Technical support for researchers, #C external libraries developing.
2010-2013
2009-2010
Education & Certification
Cloud systems and services. Specialization.
University Oberta de Catalunya
Cloud computing. IaaS: AWS, Azure, Google, etc. PaaS (Heroku) & Saas. DevOps (Docker). Encloud computing & security.
2019
Master of Science in Bioinformatics & Biostatistics.
University Barcelona, University Oberta de Catalunya
Computational Genomics, Omics data analysis, Regression analysis, Statistical inference, Molecular and Structural biology, Multivariate analysis, Functional genomics, Computer programming, R, Python.
2014-2016
BSc in Computer Systems Engineering, Computer Science.
Advanced programming, Design of databases, Data structure, Advanced mathematics, Statistics.
2007-2011
Programing Course, Specialization Course in Programming iOS for iPhone and iPad
2012-2013
Programing Course, Advanced Java
Java Server Pages (JSP), XML, Servlets, DB access with JDBC, etc.
2012
Programing Course, PHP
2009
Publications
D.Vijaykrishna, Y.M. Deng, M.L. Grau, M.Kay, A. Suttie, P. Dussart, I.G. Barr, E.A. Klaason. Genomic diversity of influenza A H7N4 virus in Cambodian poultry. 2019
2019
M. Linster,C. Donato,M.G Mah, M.L. Grau,J.G Low, E.E. Ooi,Y.CF. Su,G.JD Smith,D. Vijaykrishnaa. Genetic diversity of respiratory enteroviruses and rhinoviruses in febrile adults, Singapore 2007–2013. 2019
2019
M.A. Techer, R.V. Rane, M.L. Grau, J. M. K. Roberts, S.T. Sullivan, I. Liachko, A.K. Childers, J.D. Evans, A.S. Mikheyev. Genomic analyses of sibling honey bee ectoparasitic mite species show divergent strategies of adaptation. bioRxiv 2019 Jan doi: 10.1101/512988
2019
S.D. Aird, N.J da Silva, L. Qiu, A. Villar-Briones, V. Aparecida Saddi, M. Pires de Campos Telles, M.L. Grau and A.S. Mikheyev. Coralsnake Venomics: Analyses of Venom Gland Transcriptomes and Proteomes of Six Brazilian Taxa. Toxins 2017 Jun 8;9(6). pii: E187. doi: 10.3390/toxins9060187
2017
A.S. Mikheyev, A. Zwick3,M.J.L. Magrath, M.L. Grau, L. Qiu, Y.N. Su, D. Yeates. Museum genomics confirms that the Lord Howe Island stick insect survived extinction. Current Biology. Current Biology. Oct 2017. doi: http://dx.doi.org/10.1016/j.cub.2017.08.058
2017
CONTRIBUTIONS
M. Helmkampf, A.S. Mikheyev, Y. Kang, J. Fewell and J. Gadau. Gene expression and variation in social aggression by queens of the harvester ant Pogonomyrmex californicus. Molecular Ecology, 25: 3716–3730, 2016
2016
C. Morandin, M.M.Y. Tin, S. Abril, C. Gómez, L. Pontieri, M. Schiøtt, L. Sundström, K. Tsuji, J.S. Pedersen, H. Helanterä and A.S. Mikheyev. Comparative transcriptomics reveals the conserved building blocks involved in parallel evolution of diverse phenotypic traits in ants. Genome Biology 17:43, 2016
2016
G. Fischer, F.L. Azorsa, F.H. Garcia, A.S. Mikheyev, E.P. Economo. Two new phragmotic ant species from Africa: morphology and next-generation sequencing solve a caste association problem in the genus Carebara Westwood. ZooKeys 525: 77-105, 2015
2015
C.R. Smith S. Helms Cahan, C. Kemena, S.G. Brady, W. Yang, E. Bronberg-Bauer, T. Eriksson, J. Gadau, M. Helmkampf, D. Gotzek, M. O. Miyakawa, A.V. Suarez and A.S. Mikheyev, How do genomes create novel phenotypes? Insights from the loss of the worker caste in ant social parasites, Molecular Biology and Evolution, 32: 2919-2931, 2015
2015
M.M.Y. Tin, F.E. Rheindt, E. Cros and A.S. Mikheyev, Degenerate adaptor sequences for detecting PCR duplicates in reduced representation sequencing data improve genotype calling accuracy. Molecular Ecology Resources. 15:2 329-336, 2015.
2015
A.S. Mikheyev and M.M.Y. Tin. A first look at the Oxford Nanopore MinION sequencer. Molecular Ecology Resources. 14: 1097–1102. 2014
2014
CONFERENCES
11 TH ANNUAL CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND SURVEILLANCE (CEIRS) NETWORK MEETING.
New York, USA. 2018.(Poster presentation).
2018